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B Katzung, SB Masters AJ Trevor (Editors). Stahl SM (2014): The Prescriber's Guide. Cite articleChlorpromazine (Largactil) is a first generation typical antipsychotic. It is primarily used for the treatment of adult psychosis including schizophrenia, mania, and childhood schizophrenia. Chlorpromazine is a phenothiazine, meaning it has tranquilizing properties and potentiates general CNS depression.

Therapy sessions may need to be altered due to tiredness or other side effects. Dosage is dependent on the indication for chlorpromazine and is most commonly administered either orally or intramuscularly (IM). Nausea and vomiting will take 10-25 mg every 4-6 hours orally or 25-50 mg IM every 3-4 hours. For chlorpromazine, the route of administration may have differing side effects.

The pharmacokinetics of chlorpromazine is also not fully understood and varies per the individual and route of administration. The elimination half-life is thought to be a series of phases, with the early phase in 2-3 hours, an intermediate phase of 15 hours, and a late phase of up to 60 days. Because of this, the physical therapist should be aware that side effects may linger after the dose is administered.

Like most typical antipsychotics, chlorpromazine has an extensive side effect profile. Some of the more common side effects exclusive to chlorpromazine include contact dermatitis, photosensitivity, hyperglycemia, and prolactin elevation. Postural hypotension could increase the risk of falls. Heart rate, respiration, blood sugar, and blood pressure should be monitored during the treatment session.

Certain therapeutic modalities should be avoided due to skin sensitivities and photosensitivity, as well as caution with manual techniques. As chlorpromazine is a general sedative, scheduling the patient around dosages may be necessary to prevent drowsiness during exercises. Psychotic disorders in general increase the risk of suicidal thoughts and behaviors. Suicide and psychiatric diagnosis: a worldwide perspective.

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